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Ketamine’s history is enmeshed with the histories of both general anesthesia and drugs of abuse. As opposed to local anesthetics, which numb just the nerves or the region where they are injected, general anesthetics induce unconsciousness and a lack of response to painful stimuli. With patients anesthetized and their muscles relaxed, surgeons perform long, complicated operations that would never be possible on conscious, sentient patients.
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